In 2025, decentralized finance (DeFi) continues to expand across chains, assets, and regions. Traders and investors no longer need to rely solely on centralized platforms—they’re moving on-chain, where automation tools like Coinrule are making it easier than ever to deploy strategies without writing a single line of code.
If you’re looking to automate your portfolio, farming, or trading activity, choosing the top protocols to connect with Coinrule is essential. In this guide, we’ll explore the best-performing DeFi platforms compatible with Coinrule and how you can maximize your returns through automation.
Why Automating DeFi with Coinrule Makes Sense
Coinrule’s no-code interface is designed for traders of all skill levels. Whether you’re running a DCA strategy or managing LP positions, Coinrule lets you build powerful if-this-then-that rules that execute automatically across supported blockchains and protocols.
Top benefits of automating with Coinrule:
- No-code setup for advanced on-chain strategies
- 24/7 execution on Base, Arbitrum, Ethereum, and more
- Integrations with the most active DeFi protocols
- Risk management tools built into automation workflows
Coinrule Is Now Live Across Leading DeFi Chains
Coinrule supports real-time strategy automation on the following blockchains:
- Ethereum Mainnet
- Base (Coinbase L2)
- Arbitrum
- Hyperliquid (DeFi perpetuals layer)
Top Protocols to Connect with Coinrule
Below are the most compatible and widely used DeFi platforms that integrate well with Coinrule’s automation layer:
1. Uniswap (Ethereum / Base / Arbitrum)
- Category: Decentralized Exchange (DEX)
- Why Use It: High liquidity, wide token support
- Best Automation Use: DCA into ETH or exit a token position at RSI 70+
2. Aerodrome (Base)
- Category: Incentivized DEX
- Why Use It: High-yield LPs, emissions opportunities
- Best Automation Use: Auto-exit LPs when yield drops or TVL spikes
3. Velodrome (Optimism)
- Category: DEX + DeFi hub
- Why Use It: Reward-rich emissions, deep liquidity
- Best Automation Use: Rotate tokens during new gauge emissions
4. Camelot (Arbitrum)
- Category: Launchpad + Trading
- Why Use It: Access to early projects
- Best Automation Use: Set alerts or trades during new listings
5. Balancer (Ethereum / Polygon)
- Category: Dynamic Liquidity Pools
- Why Use It: Custom portfolio weights, token sets
- Best Automation Use: Auto-rebalance when pool ratios diverge
6. Hyperliquid (Custom L2)
- Category: Perpetual Futures DEX
- Why Use It: Onchain leverage trading with low fees
- Best Automation Use: Short or long BTC/ETH based on trend or funding rate
Strategy Templates You Can Run Today with Coinrule
|
Strategy Goal |
Coinrule Automation Example |
|
Yield Farming Rotation |
“Every 7 days, switch to the highest APR LP on Velodrome or Aerodrome.” |
|
Market Trend Capture |
“If ETH price drops 5% in 24h, buy on Uniswap; sell on 10% recovery” |
|
Volatility Hedge |
“Short BTC on Hyperliquid if RSI > 80 on daily chart” |
|
Portfolio Rebalancing |
“Rebalance into stablecoins if TVL drops >15% on Arbitrum protocols.” |
Why These Are the Top Protocols for 202
Each listed DeFi protocol offers:
- High on-chain activity and global usage
- Reliable infrastructure and smart contract audits
- Deep liquidity and scalable token pairs
- Cross-chain compatibility with Coinrule’s automation engine
- Built-in reward incentives (e.g., emissions, airdrops, LP APYs)
By selecting these top protocols, traders gain access to dependable infrastructure that matches Coinrule’s automation capabilities.
Final Thoughts: Automate Smarter with Coinrule
As DeFi continues to evolve in 2025, combining top protocols with Coinrule’s no-code automation empowers traders globally to act faster, hedge risk better, and scale strategies with precision.
Coinrule isn’t just a tool, it’s your automation companion in a decentralized world. And by integrating with the top protocols across Ethereum, Base, Arbitrum, and Hyperliquid, Coinrule helps you unlock DeFi’s full potential on your terms, in your timezone.